Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure
Identifieur interne : 000227 ( France/Analysis ); précédent : 000226; suivant : 000228Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure
Auteurs : Zhihui Xu [République populaire de Chine] ; Xiaoqiang Ren [République populaire de Chine] ; Yan Liu [République populaire de Chine] ; Xiaodong Li [République populaire de Chine] ; Siyu Bai [République populaire de Chine] ; Yanwei Zhong [République populaire de Chine] ; Lin Wang [République populaire de Chine] ; Panyong Mao [République populaire de Chine] ; Huifen Wang [République populaire de Chine] ; Shaojie Xin [République populaire de Chine] ; Vincent Wai-Sun Wong [République populaire de Chine] ; Henry Lik-Yuen Chan [République populaire de Chine] ; Fabien Zoulim [France] ; Dongping Xu [République populaire de Chine]Source :
- Journal of Gastroenterology [ 0944-1174 ] ; 2011-03-01.
English descriptors
- KwdEn :
Abstract
Abstract: Objective: To investigate the features of hepatitis B virus (HBV) basal core promoter/precore (BCP/PC) mutations and genotypes in a large number of mild/severe chronic hepatitis B (CHB-M/CHB-S), and acute-on-chronic liver failure (ACLF) patients and analyze the clinical implications of the virologic features. Patients and methods: Sera of 793 (325 CHB-M, 170 CHB-S, and 298 ACLF) patients admitted to or who had visited Beijing 302 Hospital from January 2005 to December 2008 were collected and successfully amplified for the HBV BCP/PC and a 1225-bp-long S/Pol (nt 54–1278) gene regions. Biochemical and serological parameters and HBV DNA level were routinely performed. Viral DNA was extracted and subjected to a nested PCR. Genotypes/subgenotypes were determined based on complete genomic sequence or on analysis of the 1225-bp-long S/Pol-gene sequence. HBV genotyping was performed by direct PCR sequencing followed by molecular evolutionary analysis of the viral sequences. A P value of <0.05 (two-sided) was considered to be statistically significant. Conclusions: Our findings suggest that CHB patients infected with BCP/PC mutant viruses are more susceptible to severe hepatitis and ACLF than those with the BCP/PC wild-type virus and that ACLF patients with PC mutant viruses have an increased risk of death. As such, the HBV PC mutation is a potential predictive indicator of ACLF outcome.
Url:
DOI: 10.1007/s00535-010-0315-4
Affiliations:
- France, République populaire de Chine
- Auvergne-Rhône-Alpes, Rhône-Alpes
- Lyon, Pékin, Sha Tin
- Université chinoise de Hong Kong
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ISTEX:E0C7FCC069FEDE1A2C6F6010B6CB8895F3EF8BA0Le document en format XML
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last="Liu">Yan Liu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Viral Hepatitis Research Laboratory, Beijing Institute of Infectious Diseases, 100039, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Liver Failure Research Center, Beijing 302 Hospital, 100039, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Xiaodong" sort="Li, Xiaodong" uniqKey="Li X" first="Xiaodong" last="Li">Xiaodong Li</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Viral Hepatitis Research Laboratory, Beijing Institute of Infectious Diseases, 100039, Beijing</wicri:regionArea><placeName><settlement 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last="Xin">Shaojie Xin</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Viral Hepatitis Research Laboratory, Beijing Institute of Infectious Diseases, 100039, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Liver Failure Research Center, Beijing 302 Hospital, 100039, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wong, Vincent Wai Sun" sort="Wong, Vincent Wai Sun" uniqKey="Wong V" first="Vincent Wai-Sun" last="Wong">Vincent Wai-Sun Wong</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Chan, Henry Lik Yuen" sort="Chan, Henry Lik Yuen" uniqKey="Chan H" first="Henry Lik-Yuen" last="Chan">Henry Lik-Yuen Chan</name><affiliation wicri:level="4"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medicine and Therapeutics and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong</wicri:regionArea><orgName type="university">Université chinoise de Hong Kong</orgName><placeName><settlement type="city">Sha Tin</settlement></placeName></affiliation></author><author><name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U871, 69003, Lyon</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Hepatology and Gastroenterology, Hospices Civils de Lyon, Hôtel Dieu Hospital, 69002, Lyon</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Xu, Dongping" sort="Xu, Dongping" uniqKey="Xu D" first="Dongping" last="Xu">Dongping Xu</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Viral Hepatitis Research Laboratory, Beijing Institute of Infectious Diseases, 100039, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Liver Failure Research Center, Beijing 302 Hospital, 100039, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Gastroenterology</title><title level="j" type="abbrev">J Gastroenterol</title><idno type="ISSN">0944-1174</idno><idno type="eISSN">1435-5922</idno><imprint><publisher>Springer Japan</publisher><pubPlace>Japan</pubPlace><date type="published" when="2011-03-01">2011-03-01</date><biblScope unit="volume">46</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="391">391</biblScope><biblScope unit="page" to="400">400</biblScope></imprint><idno type="ISSN">0944-1174</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0944-1174</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute-on-chronic liver failure</term><term>Basal core promoter mutation</term><term>Genotype</term><term>Hepatitis B virus</term><term>Precore mutation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Objective: To investigate the features of hepatitis B virus (HBV) basal core promoter/precore (BCP/PC) mutations and genotypes in a large number of mild/severe chronic hepatitis B (CHB-M/CHB-S), and acute-on-chronic liver failure (ACLF) patients and analyze the clinical implications of the virologic features. Patients and methods: Sera of 793 (325 CHB-M, 170 CHB-S, and 298 ACLF) patients admitted to or who had visited Beijing 302 Hospital from January 2005 to December 2008 were collected and successfully amplified for the HBV BCP/PC and a 1225-bp-long S/Pol (nt 54–1278) gene regions. Biochemical and serological parameters and HBV DNA level were routinely performed. Viral DNA was extracted and subjected to a nested PCR. Genotypes/subgenotypes were determined based on complete genomic sequence or on analysis of the 1225-bp-long S/Pol-gene sequence. HBV genotyping was performed by direct PCR sequencing followed by molecular evolutionary analysis of the viral sequences. A P value of <0.05 (two-sided) was considered to be statistically significant. Conclusions: Our findings suggest that CHB patients infected with BCP/PC mutant viruses are more susceptible to severe hepatitis and ACLF than those with the BCP/PC wild-type virus and that ACLF patients with PC mutant viruses have an increased risk of death. As such, the HBV PC mutation is a potential predictive indicator of ACLF outcome.</div></front></TEI><affiliations><list><country><li>France</li><li>République populaire de Chine</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li><li>Pékin</li><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xu, Zhihui" sort="Xu, Zhihui" uniqKey="Xu Z" first="Zhihui" last="Xu">Zhihui Xu</name></noRegion><name sortKey="Bai, Siyu" sort="Bai, Siyu" uniqKey="Bai S" first="Siyu" last="Bai">Siyu Bai</name><name sortKey="Bai, Siyu" sort="Bai, Siyu" uniqKey="Bai S" first="Siyu" last="Bai">Siyu Bai</name><name sortKey="Chan, Henry Lik Yuen" sort="Chan, Henry Lik Yuen" uniqKey="Chan H" first="Henry Lik-Yuen" last="Chan">Henry Lik-Yuen Chan</name><name sortKey="Li, Xiaodong" sort="Li, Xiaodong" uniqKey="Li X" first="Xiaodong" last="Li">Xiaodong Li</name><name sortKey="Li, Xiaodong" sort="Li, Xiaodong" uniqKey="Li X" first="Xiaodong" last="Li">Xiaodong Li</name><name sortKey="Liu, Yan" sort="Liu, Yan" uniqKey="Liu Y" first="Yan" last="Liu">Yan Liu</name><name sortKey="Liu, Yan" sort="Liu, Yan" uniqKey="Liu Y" first="Yan" last="Liu">Yan Liu</name><name sortKey="Mao, Panyong" sort="Mao, Panyong" uniqKey="Mao P" first="Panyong" last="Mao">Panyong Mao</name><name sortKey="Mao, Panyong" sort="Mao, Panyong" uniqKey="Mao P" first="Panyong" last="Mao">Panyong Mao</name><name sortKey="Ren, Xiaoqiang" sort="Ren, Xiaoqiang" uniqKey="Ren X" first="Xiaoqiang" last="Ren">Xiaoqiang Ren</name><name sortKey="Ren, Xiaoqiang" sort="Ren, Xiaoqiang" uniqKey="Ren X" first="Xiaoqiang" last="Ren">Xiaoqiang Ren</name><name sortKey="Wang, Huifen" sort="Wang, Huifen" uniqKey="Wang H" first="Huifen" last="Wang">Huifen Wang</name><name sortKey="Wang, Huifen" sort="Wang, Huifen" uniqKey="Wang H" first="Huifen" last="Wang">Huifen Wang</name><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name><name sortKey="Wong, Vincent Wai Sun" sort="Wong, Vincent Wai Sun" uniqKey="Wong V" first="Vincent Wai-Sun" last="Wong">Vincent Wai-Sun Wong</name><name sortKey="Xin, Shaojie" sort="Xin, Shaojie" uniqKey="Xin S" first="Shaojie" last="Xin">Shaojie Xin</name><name sortKey="Xin, Shaojie" sort="Xin, Shaojie" uniqKey="Xin S" first="Shaojie" last="Xin">Shaojie Xin</name><name sortKey="Xu, Dongping" sort="Xu, Dongping" uniqKey="Xu D" first="Dongping" last="Xu">Dongping Xu</name><name sortKey="Xu, Dongping" sort="Xu, Dongping" uniqKey="Xu D" first="Dongping" last="Xu">Dongping Xu</name><name sortKey="Xu, Zhihui" sort="Xu, Zhihui" uniqKey="Xu Z" first="Zhihui" last="Xu">Zhihui Xu</name><name sortKey="Zhong, Yanwei" sort="Zhong, Yanwei" uniqKey="Zhong Y" first="Yanwei" last="Zhong">Yanwei Zhong</name><name sortKey="Zhong, Yanwei" sort="Zhong, Yanwei" uniqKey="Zhong Y" first="Yanwei" last="Zhong">Yanwei Zhong</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name></region><name sortKey="Zoulim, Fabien" sort="Zoulim, Fabien" uniqKey="Zoulim F" first="Fabien" last="Zoulim">Fabien Zoulim</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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